Dichloromethane (DCM) is the core solvent for the extraction of pharmaceutical intermediates. It has the advantages of strong solubility and moderate boiling point. However, the traditional process generally has problems such as high solvent residue (>500ppm), low separation efficiency (single-stage extraction rate <85%), and severe emulsification. Tiei Extraction CWL-M series centrifugal extractor has successfully solved industry problems through centrifugal field enhanced mass transfer technology and intelligent process control, achieving technological breakthroughs in the production of cephalosporin and quinolone intermediates.
- Ultra-gravity Field Enhanced Separation
The equipment adopts a three-stage countercurrent extraction design. Under the action of 2000-3000G centrifugal force, the two-phase contact time is shortened to within 15 seconds, which is 5 times more efficient than the traditional static stratification. The mixing-clarification dual-zone structure customized for the characteristics of the DCM-water system reduces the mass transfer unit height (HTU) to less than 30cm, and the stage efficiency is stabilized at 92%-95%. - Safety Explosion-proof System
Integrated ExdIIBT4 explosion-proof certified motor, nitrogen sealing protection system and solvent concentration online monitoring module to ensure VOCs emission concentration <50mg/m³. - Comparison of Actual Application Data
The case of a cefixime intermediate project of a listed pharmaceutical company shows:
Extraction efficiency: Under the three-stage countercurrent process, the target yield is increased from 82% of the traditional process to 96.5%, and the solvent loss is reduced by 42%.
Product quality: organic residue (DCM) is reduced to below 80ppm, meeting the ICH Q3C requirements.
Economic benefits: The annual processing capacity of the production line is 5,000 tons, and the solvent recovery system saves more than 3 million yuan in costs each year. - Tiei Extraction Full Industry Chain Service Capabilities
Process development: Provide a full set of test equipment from small test to pilot test to industrialization, and complete the process feasibility report within 72 hours.
Compliance support: Assist customers to complete equipment DQ/IQ/OQ verification documents, and provide EU GMP audit simulation services.
Global certification: ASME, CE, ATEX and other international certifications have been obtained, and products are exported to 18 countries.
Welcome contact us for more details.
Email: sales@tieiextraction.com
Whatsapp: +86 19069612820
